The rates are remarkably similar across all three, despite their different mechanisms: Semaglutide: Nausea approximately 18%, diarrhea approximately 12%, vomiting approximately 8% Tirzepatide: Nausea 17-22% (dose dependent), diarrhea 13-16%, vomiting 6-10% Retatrutide: Nausea 16-25% (dose dependent), diarrhea 15-22%, vomiting 8-13% The pattern holds consistently
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The MRI also tells me if the tear is from gradual wear over time (degenerative), which is common in older patients and usually responds well to non-surgical care
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In a real-world study summarizing data collected from five European countries plus Canada in 20152016, between 4 and 24% of patients had switched treatments at 1 year after their first GLP-1 RA prescription [10]
